do you have page file enabled? I have 128gb of ram in my system and from my experience, some program were poorly designed and may not touch free ram when they’re suppose to, and look for virtual space/page file. I use to have it turned off and ran into issues so now I keep them on at least 16gb of it. if you have it set at 0 or very low, I’d start try with 10-20gb of it to see if it helps.
also, are you using UHD/enhanced graphics?