the Mesopotamians had the Kungas, the first known human-made hybrid animal, which were used in combat as War Chariots.
As mentioned in the article below, they were “bioengineered war machines”, and can’t be created again anymore, since the last hemippe perished more than a century ago.
[Scientists Identify Earliest Known Human-Made Hybrid Found in 4500-Year-Old Tomb (earthlymission.com)](https://earthlymission.com/kunga-discovery-earliest-known-hybrid-animal-breed-donkey-wild-ass
this is a copy paste from another thread